2014 Fiscal Year Final Research Report
Development of radical reaction using bromoalkynes and synthesis of natural products
| Project/Area Number |
25860013
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemical pharmacy
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| Research Institution | Hoshi University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | ラジカル環化反応 / ヨウ化サマリウム / ハロアルキン / アルデヒド / ケトン |
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| Outline of Final Research Achievements |
Radical reaction is the most of important reactions in organic chemistry to form carbon-carbon bonds and carbon-halogen bonds, which applied to synthesize natural products, medicines and polymer. Therefore, it is important to develop a new and a efficient methodology. We have successfully developed that SmI2-mediated reductive cyclization of haloalkynes with aldehydes, affording (Z)- bromoallyl alcohol in good to excellent yields. Further, radical cyclization of haloalkynes with ketones are under investigation of our laboratory.
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| Free Research Field |
有機化学
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