2014 Fiscal Year Final Research Report
Regulation of intercellular crosstalk by induced ubiquitin ligase SSB
| Project/Area Number |
25860043
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biological pharmacy
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| Research Institution | Nagoya University |
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Principal Investigator |
FUMIHIKO Okumura 名古屋大学, 理学(系)研究科(研究院), 助教 (00507212)
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| Co-Investigator(Renkei-kenkyūsha) |
嘉村 巧 (40333455)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | ユビキチン / ガン |
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| Outline of Final Research Achievements |
The aim is to identify the molecular mechanism which regulates intercellular crosstalk by SOCS box protein SSB.
We identified SSB-binding proteins. Given that SSB is a ubiquitin ligase, we checked the stability of SSB-binding proteins and found that one of the candidate accumulated by knockdown of SSB. The candidate has been reported as a tumor suppressor gene and also as a oncogene. We are currently studying the physiological function of the candidate protein.
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| Free Research Field |
ガン
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