2015 Fiscal Year Final Research Report
A novel secretory protein neudesin as a target for anti-obesity drug
| Project/Area Number |
25860045
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biological pharmacy
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| Research Institution | Kobe Pharmaceutical University (2015)
Kyoto University (2013-2014) |
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Principal Investigator |
Ohta Hiroya 神戸薬科大学, 薬学部, 研究員 (40638988)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | neudesin / 肥満 / エネルギー消費 / 交感神経系 |
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| Outline of Final Research Achievements |
We tried to elucidate the physiological roles of Neudesin, a secretory protein, using Neudesin KO mice. We showed that Neudesin KO mice were resistant to high-fat diet induced obesity. Food intake and absorption of fat were comparable between WT and Neudesin KO mice. However, Neudesin KO mice showed increased energy expenditure caused by enhanced sympathetic nervous activity. These results suggest that Neudesin play roles in the development of obesity, and neudesin might be a novel target for anti-obesity drug.
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| Free Research Field |
分子生物学
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