Elucidation of the molecular mechanism underlying neural stem cell differentiation regulated by a specific combination of glycans and their carrier proteins

2014 Fiscal Year Final Research Report

• Project/Area Number: 25860053
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Biological pharmacy
• Research Institution: Nagoya City University
• Principal Investigator: HIROKAZU Yagi 名古屋市立大学, 薬学研究科(研究院), 講師 (70565423)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 糖鎖修飾 / LewisX / HNK-1

Outline of Final Research Achievements

In this research project, we have focused on the system that the specific glycoproteins carry the specific glycans such as LewisX and HNK-1 carbohydrates, and attempted to elucidate the molecular mechanism underlying the definite glycosylation in neural stem cells. Furthermore, we have identified the molecule interacted with a specific glycan-possessing protein. The fact raises the possibility that a specific combination of glycans and their carrier proteins involved in the signaling pathways for the maintenance and differentiation of neural stem cells.

Free Research Field

生化学