2014 Fiscal Year Final Research Report
A novel mechanism through regulation of tau phosphorylation and neuroprotective effect by drugs for the treatment of Alzheimer's disease
| Project/Area Number |
25860069
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pharmacology in pharmacy
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| Research Institution | Doshisha Women's College of Liberal Arts |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | アルツハイマー病 / ニューロン / 神経保護作用 |
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| Outline of Final Research Achievements |
Donepezil is widely used as a therapeutic drug for Alzheimer's disease. It prevents cortical neurons against glutamate neurotoxicity through nicotinic acetylcholine receptors, followed by the phosphatidylinositol 3-kinase (PI3K)-Akt pathway. In cortical cultures, donepezil inhibited the activation of glycogen synthase kinase-3β(GSK-3β) through the PI3K-Akt pathway. Furthermore, downstream signaling of inhibition of GSK-3β activity involved the expression level of β-catenin and site-specific tau phosphorylation, rather than the expression level of Bcl-2.
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| Free Research Field |
医歯薬学
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