2015 Fiscal Year Final Research Report
drug discovery research targets for cosmetic compounds from unused plants
| Project/Area Number |
25860078
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Natural medicines
|
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| Research Institution | Hiroshima University |
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Principal Investigator |
|
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| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Keywords | 糖化抑制活性 / メラニン産生抑制活性 / Ixora undulata / Linaria japonica |
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| Outline of Final Research Achievements |
Advanced glycation endproducts, which readily form and accumulate with sustained hyperglycemia, contribute to the development of diabetic complications and, as such, are considered a potential therapeutic target. Some isolated compounds from two plants showed strong inhibitory activity toward AGEs formation, the inhibitory activity of a positive control, aminoguanidine, being 2.48 mM. The current results ndicate that, in comparison with the reference compound, aminoguanidine, which once entered phase II clinical trials, but was withdrawn because of its side effects, flavonoid glycosides were clearly more efficient in inhibiting the formation of AGEs. Thus, these compounds seem to be worthy of consideration as potential therapeutic agents for diabetic complications and related diseases though additional biological evaluation.
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| Free Research Field |
天然物化学
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