2015 Fiscal Year Final Research Report
Establishment of a New Method for Huperzine A Production using Plant Endophytic Fungi
| Project/Area Number |
25860080
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Natural medicines
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| Research Institution | Nagoya City University (2015)
Nihon University (2013-2014) |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | huperzine A / アルツハイマー病 / 植物内生糸状菌 / Phoma sp. / Lycopodium alkaloid / serralongamine / マクロファージ泡沫化阻害活性 |
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| Outline of Final Research Achievements |
We discovered a fungal strain Lsl3 from Lycopodium serratum var. longipetiolatum produced huperzine A, an anti-Alzheimer’s disease drug candidate from the traditional Chinese medicine Qian Ceng Ta (Huperzia serrata). The strain Lsl3 was classified to the genus Phoma based on molecular phylogenetic analysis. Also we isolated four new alkaloids, serralongamines A-D, from L. serratum var. longipetiolatum and elucidated their stuructures on the basis of spectroscopic data. Serralongamines B and D exhibited the inhibitory activity against foam cell formation in human macrophages, one of characteristic features of early atherosclerotic lesions.
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| Free Research Field |
天然物化学
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