2014 Fiscal Year Final Research Report
Development of novel molecular target drug for activated Ras protein by the specific protein degradation system
| Project/Area Number |
25860095
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Drug development chemistry
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| Research Institution | National Institute of Health Sciences |
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Principal Investigator |
HATTORI TAKAYUKI 国立医薬品食品衛生研究所, 遺伝子医薬部, 主任研究官 (50377751)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | タンパク質分解 / プロテインノックダウン / Ras / 癌分子標的治療 |
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| Outline of Final Research Achievements |
The aim this study is to develop the SNIPER that specifically target activated mutant Ras proteins by protein knockdown system. We synthesized two bestatin-Ras-binding compounds hybrids (SNIPERs), however both compounds did not degrade Ras protein in cells. To identify more Ras ligand candidate compounds we performed in silico docking simulation and obtained 728 candidates. In addition, we developed a system that makes us to predict performance of the protein knockdown against proteins of interest by SNIPER before identifying specific ligands for proteins of interest.
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| Free Research Field |
医歯薬学
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