Analysis of cardiac sodium channel-related gene polymorphisms for dose adjustment of anti-arrhythmic drugs

2015 Fiscal Year Final Research Report

• Project/Area Number: 25860106
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Medical pharmacy
• Research Institution: University of Tsukuba
• Principal Investigator: DOKI Kosuke 筑波大学, 医学医療系, 講師 (90620881)
• Research Collaborator: HOMMA MASATO 筑波大学, 医学医療系, 教授 ; AONUMA KAZUTAKA 筑波大学, 医学医療系, 教授 ; KUGA KEISUKE 筑波大学, 医学医療系, 教授
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 心筋ナトリウムチャネル / ナトリウムチャネル遮断薬 / 遺伝子多型

Outline of Final Research Achievements

Inter-individual variability in anti-arrhythmic efficacy of sodium channel blockers was examined on the basis of cardiac sodium channel-related gene polymorphism analysis. Asian-specific promoter haplotype of the cardiac sodium channel gene was associated with effectiveness in lower concentration of sodium channel blockers. β1-adrenergic receptor polymorphism led to reduced anti-arrhythmic efficacy of sodium channel blocker. These findings suggest that cardiac sodium channel-related gene polymorphisms are important for dose adjustment of sodium channel blockers.

Free Research Field

臨床薬理学