Critical role of MATE in renal dopamine secretion into tubular lumen

2014 Fiscal Year Final Research Report

• Project/Area Number: 25860114
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Medical pharmacy
• Research Institution: Kyushu University (2014); Kyoto University (2013)
• Principal Investigator: KAJIWARA MOTO 九州大学, 医学(系)研究科(研究院), 助教 (70645506)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: トランスポーター / ナトリウム / MATE / ドパミン / 利尿 / 腎臓

Outline of Final Research Achievements

The intrarenal dopaminergic system is likely responsible for regulating over 50% of net renal salt and water excretion when salt intake increases. Although dopamine synthesis is localized at proximal tubular cells, the molecular mechanism underlying dopamine secretion into urine remains unknown. We analyzed transport properties of dopamine by human and mouse multidrug and toxin extrusion (MATE) and measured urinary dopamine and sodium in wild-type and Mate1 null mice. Dopamine uptake by MATE exhibits saturable kinetics. The amount of urinary dopamine and sodium was decreased in Mate1 null mice. In conclusion, MATE plays a critical role in dopamine secretion into tubular lumen and promotes natriuresis.

Free Research Field

医歯薬学