2014 Fiscal Year Final Research Report
The effect of anticancer agent induced gastrointestinal damage on drug absorption
| Project/Area Number |
25860125
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical pharmacy
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| Research Institution | Keio University |
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Principal Investigator |
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| Research Collaborator |
TSUJII Kazunari
YOTSUMOTO Keiichi
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | 消化管障害 / 5-FU / ダビガトラン |
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| Outline of Final Research Achievements |
We evaluated the effects of 5-FU induced gastrointestinal damage on dabigatran pharmacokinetics(PK) and pharmacodynamics(PD) in rats. After oral administration of DABE, the PK parameters of Cmax and AUC of DAB in the 5-FU group were decreased by 30% compared to that of control group. Moreover, the PD parameter of activated partial thromboplastin time (aPTT) in the 5-FU group was also reduced. We concluded that intensive monitoring of DABE PK/PD under treatment with 5-FU is required.
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| Free Research Field |
臨床薬物動態学
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