Delivery of erythropoietin-loaded PLGA nanospheres to central nervous system via blood-brain barrier transport : Therapy for neonatal hypoxic-ischemic encephalopathy

2014 Fiscal Year Final Research Report

• Project/Area Number: 25860131
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Medical pharmacy
• Research Institution: Mukogawa Women's University
• Principal Investigator: HAZEKAWA Mai 武庫川女子大学, 薬学部, 助教 (10509186)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: エリスロポエチン / ナノスフェア / 自己修復 / 脳性小児麻痺 / PLGA / 脳移行性 / 徐放性製剤 / 初期バースト

Outline of Final Research Achievements

The purpose of this study was development of erythropoietin-loaded poly (lactide-co-glycolide) nanospheres for therapy of neonatal hypoxic-ischemic encephalopathy. Erythropoietin was encapsulated by poly as slow release formulation to reduce side effects. Furthermore, this particle showed low initial burst and high blood brain barrier permeability when this particle was prepared at glass transition temparatures of PLGA. These results were attributed to improvement the structure of surface in particle and decrease of specific surface area in particle. It was suggested that this particle might be useful in therapy for neonatal hypoxic-ischemic encephalopathy.

Free Research Field

医療薬学・製剤学