An analysis of TMEM16F KO mice as the model of Scott Syndrome

2014 Fiscal Year Final Research Report

• Project/Area Number: 25860162
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General physiology
• Research Institution: Kyoto University
• Principal Investigator: FUJII Toshihiro 京都大学, 医学(系)研究科(研究院), 助教 (30580104)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: TMEM16F / 血小板 / スコット症候群 / in vivo イメージング / phosphatidylserine

Outline of Final Research Achievements

TMEM16F was found a Ca2+-dependent phospholipid scramblase and a point mutation of TMEM16F from patient with Scott syndrome, a mild bleeding disorder. We investigated TMEM16F-deficient mice. Here we describe the phenotypes of platelet-specific TMEM16F-null mice, which resemble those of Scott syndrome patients. Platelets from these mice exhibit defects in PS exposure, microparticle release, and tissue factor-induced thrombin generation in vitro and in vivo.

Free Research Field

分子生物学