2016 Fiscal Year Final Research Report
Three dimensional imaging for the investigation of the mechanisms of generation and propagation of automaticity in the pulmonary vein myocardium
| Project/Area Number |
25860194
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
General pharmacology
|
|---|
| Research Institution | Toho University |
|---|
Principal Investigator |
|
|---|
| Research Collaborator |
TANAKA Hikaru
TAKAHARA Akira
KAWANISHI Toru
TANAKA Naoko
|
|---|
| Project Period (FY) |
2013-04-01 – 2017-03-31
|
| Keywords | 薬理学 / 肺静脈心筋 / イメージング / 自動能 / 心房細動 |
|---|
| Outline of Final Research Achievements |
We recorded the spontaneous automaticity from the myocardial layer of isolated pulmonary veins with high-speed 3-demensional confocal microscopy and glass microelectrode technique. Spontaneous automaticity was observed in isolated pulmonary vein preparations and firing frequency was enhanced by noradrenaline, while reduced by acetylcholine. Noradrenaline affected the resting membrane potential and induced local calcium oscillations followed by spontaneous automaticity. These results indicated that spontaneous automaticity of the pulmonary vein myocardium is influenced by autonomic neurotransmitters.
|
| Free Research Field |
循環薬理学
|
