Analysis of mitochondrial homeostasis through PINK1 kinase

2015 Fiscal Year Final Research Report

• Project/Area Number: 25860216
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General medical chemistry
• Research Institution: Okayama University
• Principal Investigator: Murata Hitoshi 岡山大学, 医歯(薬)学総合研究科, 講師 (90579096)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: PINK1 / ミトコンドリア / ストレス / SARM1 / NRF2

Outline of Final Research Achievements

We analyzed the mechanism of mitochondrial homeostasis through PINK1 which is one of the causing gene products of Parkinson's disease. In transcriptional regulation, we found that NRF2, an antioxidant transcription factor, regulates PINK1 expression under oxidative stress condition. In post-translational regulation, we found that SARM1 and TRAF6 bind to and stabilize PINK1 through lysine 63 chain ubiquitination. Accumulated PINK1 contributes to damaged mitochondrial degradation and cell survival.

Free Research Field

分子生物学