Analysis of neuronal cell death triggered by mitochondrial aggregation

2014 Fiscal Year Final Research Report

• Project/Area Number: 25860224
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General medical chemistry
• Research Institution: Kyushu University (2014); Tokyo Medical University (2013)
• Principal Investigator: KATO Hiroki 九州大学, 歯学研究科(研究院), 助教 (30452709)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: ミトコンドリア

Outline of Final Research Achievements

Abnormal mitochondrial distribution and aggregation at perinuclear region in neuronal cells became to be recognized as one of the cause of neurodegenerative disease. We previously reported that deletion mutants of prion protein localize to
mitochondria and induce mitochondrial aggregation. In addition, we showed that 14-3-3 zeta is essential for mitochondrial aggregation. In this study, we found that 14-3-3 gamma, eta and Tom70 are also involved in mitochondrial aggregation evoked by prion protein.

Free Research Field

細胞生物学