Epigenetic regulation of trophoblast lineage development

2015 Fiscal Year Final Research Report

• Project/Area Number: 25860259
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Human genetics
• Research Institution: National Center for Child Health and Development
• Principal Investigator: TOMIKAWA Junko 国立研究開発法人国立成育医療研究センター, その他部局等, 研究員 (80534990)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 胎盤 / エピゲノム / クロマチン構造

Outline of Final Research Achievements

Division of embryonic and extraembryonic (trophoblast) cell lineages is the first differentiation event during early development. We generated genome-wide maps of epigenetic information in embryonic stem (ES) and trophoblast stem (TS) cells. From combined analysis with formaldehyde-assisted isolation of regulatory elements (FAIRE) and chromosome conformation capture (3C) techniques, we succeeded identification of enhancers of the Tead4 gene that is required for specification of trophectoderm in pre-implantation mammalian embryos.

Free Research Field

分子生物学