2015 Fiscal Year Final Research Report
Elucidation of chemokine network associated with lung adenocarcinoma progression
| Project/Area Number |
25860272
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Human pathology
|
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| Research Institution | Yokohama City University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Keywords | ケモカイン / 肺腺癌 / 悪性化 |
|---|
| Outline of Final Research Achievements |
In the course of searching downstream molecules of KRAS induction, the chemokines were focused, and expression analysis of the genes was performed. Some of the lung cancer cell lines showed complete loss of CXCL7 mRNA expression. The mRNA expression of CXCL7 and CXCR2 in clinical samples were positively correlated. The expression of CXCL7 was observed in poorly differentiated adenocarcinoma. Some cases revealed strong expression of CXCL7 in cancer cells accompanied by prominent lymphocytic infiltration. These data suggest chemokines are involved in lung adenocarcinoma progression and cancer microenvironment.
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| Free Research Field |
人体病理学
|
