2014 Fiscal Year Final Research Report
Development of novel nucleic acid drugs for chronic hepatitis C virus infection
| Project/Area Number |
25860280
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Human pathology
|
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| Research Institution | Tokyo Medical University |
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Principal Investigator |
|
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| Project Period (FY) |
2013-04-01 – 2015-03-31
|
| Keywords | ドラッグデリバリー / HCV |
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| Outline of Final Research Achievements |
In order to achieve the treatment of chronic hepatitis C with a nucleic acid, the present study aimed at new development of nucleic acid drugs and DDS for the purpose of treatment of fibrosis and rejection of HCV. To establish a modified exosomes producing cell, the envelope expression vector of HCV and to prepare a packaging vector. Modified exosomes that were established in this study, it is possible that the beginning can be widely used for the treatment of chronic hepatitis C as a DDS for delivering efficient pharmaceutical into hepatocytes. Also packaging system enclosing the efficient nucleic acid medicine to a modified exosomes are expected to promote the realization of the nucleic acid drugs.
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| Free Research Field |
分子病理学
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