2014 Fiscal Year Final Research Report
Functional analyses of Twist-1 in malignant mesothelioma using animal carcinogensis model.
| Project/Area Number |
25860292
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Experimental pathology
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| Research Institution | Nagoya University |
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Principal Investigator |
OKAZAKI YASUMASA 名古屋大学, 医学(系)研究科(研究院), 講師 (30403489)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | 中皮腫 / Twist-1 / 鉄 / 酸化ストレス |
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| Outline of Final Research Achievements |
With the aid of this grant, Twist-1 is also detected in carbon nanotubes (CNT)-induced SM. The expression of Twist-1 was not significantly affected the life span in asbestos and CNT-induced rat MM. The expression of MDM2, which is induced by Twist-1 and works to degradate p53, and Ki67, which is a marker for cellular proliferation, were associated with Twist-1 expression. These results suggest that Twist-1 has potent proliferative effect on MM in vivo. The examination for the expression of transcriptional factors, which are reported to be a candidate for the induction of Twist-1, disclosed the relation between Twist-1 and HIF1alpha expression in CNT-induced rat MM.
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| Free Research Field |
実験病理学
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