2014 Fiscal Year Final Research Report
Analysis of chondroclasts in rheumatoid arthritis
| Project/Area Number |
25860299
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Experimental pathology
|
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| Research Institution | Iwate Medical University |
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Principal Investigator |
|
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| Project Period (FY) |
2013-04-01 – 2015-03-31
|
| Keywords | 炎症 / 関節リウマチ |
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| Outline of Final Research Achievements |
The aim of this study is to reveal the character of chondroclasts in rheumatoid arthritis (RA), so-called from the location near cartilage. The analysis using tissue from RA patients revealed that chondroclasts produce the enzymes which degrade extra cellular matrix of cartilage. The analysis of cultured cells revealed that a particular cytokine induce the differentiation into chondroclasts. Thus, it is suggested that chondroclasts are involved in cartilage degradation and joint destruction in RA patients.
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| Free Research Field |
分子生物学
|
