Role of memory T helper cells and their maintenance in vivo

2014 Fiscal Year Final Research Report

• Project/Area Number: 25860352
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Immunology
• Research Institution: Chiba University
• Principal Investigator: SHINODA Kenta 千葉大学, 医学(系)研究科(研究院), 助教 (10612195)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: アレルギー･喘息 / 免疫学

Outline of Final Research Achievements

To investigate the roles of bone marrow (BM) memory T helper (Th) cells, we evaluated humoral immune response of CD69-deficient mice which lacks them. We have clarified that BM memory Th cells are essential for efficient establishment for humoral immunity. On the other hands, it is known that there are memory Th cells that maintained at peripheral non-lymphoid tissues which are the sites of pathogen invasion. We focused on the maintenance of memory Th cells in lung tissue and found that memory Th cells are maintained within inducible bronchus-associated lymphoid tissue (iBALT). These studies will contribute the understanding of the role of memory Th cells and their maintenance in the body.

Free Research Field

免疫学