2015 Fiscal Year Final Research Report
Is anti-HIV immunity from Asia consistent with the ones from Africa, Europe, and America?
| Project/Area Number |
25860367
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Immunology
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| Research Institution | Nagasaki University |
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Principal Investigator |
MORI Masahiko 長崎大学, 熱帯医学研究所, 客員研究員 (50643988)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | HIV / HLA / KIR / タイ / 南アフリカ |
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| Outline of Final Research Achievements |
HLA: Human Leukocyte Antigen, which is a blood type of white blood cells, plays an important role in HIV viral control. Through our Thai cohort study, ①Contribution of HLA-B*57 alleles for viral control across ethnics and viral subtypes, ②HLA-B*35:05, which is unique allele among south-east population, was also detected as protective allele, ③however HLA-B*58:01 was not protective, inconsistent with African and Caucasian population, and ④Natural killer cell receptor KIR: Killer Immunoglobulin-like Receptor, which is a receptor of HLA-viral peptide complex, also effected on clinical outcome, with susceptible effect of KIR2DL3 on clinical outcomes, were identified.
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| Free Research Field |
感染症
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