2015 Fiscal Year Final Research Report
Effect of co-administration with analogs on enzyme preparation
| Project/Area Number |
25860399
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Applied pharmacology
|
|---|
| Research Institution | Meiji Pharmaceutical University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Keywords | 酵素製剤 / 基質類似体 / リソソーム病 / ファブリー病 |
|---|
| Outline of Final Research Achievements |
We found a compound which stabilize modified α-N-acetylgalactosaminidase (NAGA). The compound enhanced the uptake of modified NAGA into cultured fibroblasts derived from Fabry patients. But the compound did not enhance the uptake of modified NAGA into organs of Fabry mice. We also constructed a new screening method using thermal shift assay.
|
| Free Research Field |
生化学
|
