Development of novel preventive and therapeutic methods for complications after bone marrow transplantation: Genetic analysis and regulation of inflammation-related factors

2016 Fiscal Year Final Research Report

• Project/Area Number: 25860408
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Laboratory medicine
• Research Institution: Yamaguchi University
• Principal Investigator: YAMAGUCHI Natsu 山口大学, 医学(系)研究科(研究院), 助教 (40450671)
• Research Collaborator: TANABE Tsuyoshi 山口大学, 大学院医学系研究科, 教授 (80260678) ; TAKAHASHI Hidekazu 山口大学, 大学院医学系研究科, 講師 (90450402)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: 骨髄移植 / 遺伝子多型 / 炎症関連因子

Outline of Final Research Achievements

The NLRP inflammasomes are key regulators of innate immunity. We investigated the relationship between the single nucleotide polymorphisms (SNPs) of human NLRP1-3 genes and the prognosis of unrelated bone marrow transplantation. As a result, the interactions between the donor-recipient HLA mismatches and a recipient NLRP3 SNP were associated with grade 2-4 acute graft versus host disease (GVHD) with statistical significance. Moreover, the interaction between the donor-recipient HLA-C mismatch and a donor NLRP3 SNP were statistically significantly associated with extensive chronic GVHD. We also found that the interaction between donor cytomegalovirus serostatus and recipient NLRP3 SNP were statistically significantly associated with overall survival. These results should be validated in larger populations.

Free Research Field

分子疫学