To detect the affects of maternal exposure of OH-PCBs during pregnancy on metabolic pathway and disruption of thyroid hormones

2014 Fiscal Year Final Research Report

• Project/Area Number: 25860434
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Epidemiology and preventive medicine
• Research Institution: Hokkaido University
• Principal Investigator: ITO Sachiko 北海道大学, 環境健康科学研究教育センター, 特任助教 (90580936)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 環境疫学 / 予防医学 / 社会医学

Outline of Final Research Achievements

In a prospective birth cohort study, there was no statistical difference between any of the SNPs related to metabolic pathway and OH-PCB concentrations in maternal blood during pregnancy. We conducted multiple linear regression models to estimate the effects of maternal exposure to OH-PCBs on thyroid hormone statuses (TSH, FT4) of mother and infant. Statistical significant associations were found between maternal 4-OH-CB187 concentrations and maternal FT4, and maternalΣOH-PCB, 4-OH-CB187 and infant FT4 among only males. We measured the concentration of adiponectin and leptin in cord blood samples.

Free Research Field

医歯薬学