Epidemiological study on the association between serum adipocyte fatty acid-binding protein, fatty acid proportions and abnormal glucose metabolism.

2014 Fiscal Year Final Research Report

• Project/Area Number: 25860439
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Epidemiology and preventive medicine
• Research Institution: The University of Tokushima
• Principal Investigator: HATA Akiko 徳島大学, 大学病院, 特任助教 (20570948)
• Research Collaborator: FUNAKI Makoto 徳島大学, 病院, 特任教授 (10467821)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 脂肪酸結合蛋白質 / 疫学 / メタボリックシンドローム / 糖代謝異常 / コホート研究 / FABP4 / 脂肪酸分画

Outline of Final Research Achievements

The aim of the present study is to investigate an association between serum concentration of adipocyte fatty acid-binding protein (FABP4) and incidence of glucose metabolism disorder (GMD) or metabolic syndrome (MetS) in Japanese male workers. A prospective occupational-based study has been conducted since 2008. Male workers aged 20 to 60 years were followed up for 6 years.
The age-adjusted incidence of GMD or MetS significantly increased with increasing tertile of serum FABP4 levels at baseline (P for trend<0.05). Multivariate-adjusted HR for the development of GMD tends to increase with increasing serum FABP4 levels. Moreover, in multivariate analyses, the HR of MetS was 3.39 [95% CI:1.44-7.96] in the highest tertile when compared with the lowest tertile.
Our findings suggest that increased serum concentration of FABP4 is a risk factor for the incidence of MetS in Japanese male workers. Measuring serum levels of FABP4 may be useful to predict an onset of MetS.

Free Research Field

医歯薬学