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2015 Fiscal Year Final Research Report

The analysis for maintenance of function and chemokine receptor expression in human cytotoxic T lymphocytes under exposure to asbestos

Research Project

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Project/Area Number 25860470
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Hygiene and public health
Research InstitutionKawasaki Medical School

Principal Investigator

TAKEI NAOKO  川崎医科大学, 医学部, 助教 (00509276)

Project Period (FY) 2013-04-01 – 2016-03-31
Keywords石綿 / 中皮腫 / CTL / ケモカイン受容体 / granzyme B / perforin
Outline of Final Research Achievements

Chrysotile B (CB) asbestos exposure suppressed the induction of CTL during MLR, accompanied by the partial decrease in %CXCR3+ cells in CD8+T cells. We also prepared a sub-line of human CD8+T cells exposed to 5 μg/ml CB and analyzed the effect of CB exposure on CTL. Granzyme B+, perforin+, and IFN-gamma+ cells did not decrease in a sub-line of CD8+T cells exposed CB.

Free Research Field

衛生学・免疫学

URL: 

Published: 2017-05-10  

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