2015 Fiscal Year Final Research Report
The analysis for maintenance of function and chemokine receptor expression in human cytotoxic T lymphocytes under exposure to asbestos
| Project/Area Number |
25860470
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Hygiene and public health
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| Research Institution | Kawasaki Medical School |
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Principal Investigator |
TAKEI NAOKO 川崎医科大学, 医学部, 助教 (00509276)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 石綿 / 中皮腫 / CTL / ケモカイン受容体 / granzyme B / perforin |
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| Outline of Final Research Achievements |
Chrysotile B (CB) asbestos exposure suppressed the induction of CTL during MLR, accompanied by the partial decrease in %CXCR3+ cells in CD8+T cells. We also prepared a sub-line of human CD8+T cells exposed to 5 μg/ml CB and analyzed the effect of CB exposure on CTL. Granzyme B+, perforin+, and IFN-gamma+ cells did not decrease in a sub-line of CD8+T cells exposed CB.
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| Free Research Field |
衛生学・免疫学
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