Relationship between chemical-specific IgGs and childhood allergies

2016 Fiscal Year Final Research Report

• Project/Area Number: 25860472
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Hygiene and public health
• Research Institution: University of Occupational and Environmental Health, Japan
• Principal Investigator: Tsuji Mayumi 産業医科大学, 医学部, 准教授 (40457601)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: 小児 / アレルギー / 化学物質 / 社会医学 / 分子疫学

Outline of Final Research Achievements

Study purpose is to analyze the following association for young children.1.the sensitization situation of plastic-resin specific IgG. 2.The relationship between specific IgG antibodies and allergy symptoms.
[Material and Methods] Subjects included 202 children (mean age 19.7 months). A questionnaire survey was answered by a parent, and blood was collected to measure plastic-resin-specific IgGs and mRNA. In addition, adult blood was also collected to measure plastic-resin-specific IgGs (N=104). ［Results］Plastic-resin-specific IgG values were defined as: negative; non-detection (N.D.), positive >0μg;/ml. The ratios of positive groups for AA, BADGE, FA and PPD is following; adult; 15%, 8%, 9%, 18%. young children; 32%, 21%, 14%, 7%. In particular, AA-specific IgG positive levels had a tendency to be detected in asthmatic children.[Conclusion] In young children, there was a trend for some plastic-resin-specific IgGs to be detected in young children more frequently than in adults.

Free Research Field

社会医学