2015 Fiscal Year Final Research Report
Pathophysiological role of regulatory oligosaccharides in inflammatory bowel disease
| Project/Area Number |
25860535
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Gastroenterology
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Keywords | 制御性糖鎖 / 炎症性腸疾患 / 腸管免疫 / T細胞 / マクロファージ |
|---|
| Outline of Final Research Achievements |
In the present study we focused on the oligosaccharides on immune cells of patients with inflammatory bowel disease, and investigated the pathophysiological role of immunoregulatory oligosaccharides for colitis. We revealed that overexpression of N-Acetylglucosaminyltransferase V (GnT-V) exacerbated murine experimental colitis by inducing macrophage dysfunction. We also found using α1-6 fucosyltransferase (FUT8) deficient mice that core fucosylation of T-cell receptor is required for T-cell signaling and production of inflammatory cytokines and induction of colitis in mice. These results suggest the possibility of regulating colitis by oligosaccharides.
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| Free Research Field |
炎症性腸疾患
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