2014 Fiscal Year Final Research Report
Development of the method for predicting sensitivity to chemoradiothrapy for esophageal cancer using comprehensive gene expression profiling analysis
| Project/Area Number |
25860546
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Gastroenterology
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
|
| Keywords | 食道癌 / 化学放射線療法 / 感受性予測 / miRNA |
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| Outline of Final Research Achievements |
We performed comprehensive miRNA expression profiling analysis in pretherapeutic biopsies of responders and nonresponders in chemoradiotherapy using docectacel, nedaplatin and 5-FU of esophageal cancer, and the miRNA profiling revealed the expression of hsa-miR-625-3p and hsa-miR-4731-3p was significantly higher in the responder group. As validation analysis, we are examining the mechanism for acquiring CRT resistance using esophageal cancer cell lines transfected with the candidate miRNAs.
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| Free Research Field |
医歯薬学
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