2014 Fiscal Year Final Research Report
Massively-Parallel Sequencing reveals molecular mechanism of gastric carcinogenesis after helicobactor pylori eradication
| Project/Area Number |
25860548
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Gastroenterology
|
|---|
| Research Institution | Sapporo Medical University |
|---|
Principal Investigator |
SUZUKI Ryo 札幌医科大学, 医学部, 研究員 (60646587)
|
|---|
| Project Period (FY) |
2013-04-01 – 2015-03-31
|
| Keywords | 胃がん / メチル化 |
|---|
| Outline of Final Research Achievements |
We performed prospective cohort study designed to assess the utility of DNA methylation as a predictive marker of metachronous GC risk.We found that methylation of miR-34b/c, SFRP2 and DKK2 in the gastric body mucosa was strongly associated with a risk for metachronous GC, and miR-34b/c showed the greatest potential to serve as a predictive marker.Furthermore, we found that miR-34b/c methylation was also associated with metachronous GC risk in patients who underwent successful H. pylori eradication after treatment of their GC.
|
| Free Research Field |
消化器病
|
