2014 Fiscal Year Final Research Report
Effect of prostaglandin on the voluntary movement in rats with experimental reflux esophagitis
| Project/Area Number |
25860569
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Gastroenterology
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
KONDO Takashi 兵庫医科大学, 医学部, 助教 (90594870)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | GERD / NERD / プロスタグランジンE2 / 胸やけ |
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| Outline of Final Research Achievements |
We investigated the effects of diclofenac, a nonsteroidal anti-inflammatory drug that inhibits prostaglandin production, on induction of esophageal sensation by acid perfusion in healthy men. We concluded that diclofenac attenuated acid-induced heartburn by inhibiting PGE2 overproduction in the esophagus. Esophageal PGE2 might be involved in producing heartburn symptoms. Further studies are needed to investigate the expression of PEG2 in the esophagus or in the peripheral/central nervous system of GERD patients, and to correlate such changes with GERD symptoms.
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| Free Research Field |
神経消化器病学
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