2014 Fiscal Year Final Research Report
Role of Hrs in life cycle of hepatitis C virus
| Project/Area Number |
25860572
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Gastroenterology
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| Research Institution | Miyagi Prefectural Hospital Organization Miyagi Cancer Center |
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Principal Investigator |
TAMAI Keiichi 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), その他部局等, 研究員 (40509262)
|
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| Project Period (FY) |
2013-04-01 – 2015-03-31
|
| Keywords | HCV |
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| Outline of Final Research Achievements |
To evaluate the role of Hrs, known as ESCRT proteins, in HCV life cycle, we check the HCV-RNA in serum of chimeric liver mice. We demonstrate that the decrease of HCV-RNA in mouse serum when hrs is knocked down using adenoviral shRNA vector. Further study will be needed to elucidate the precise mechanisms of hrs-dependent HCV life cycle in humanized mice liver.
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| Free Research Field |
消化器学
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