2014 Fiscal Year Final Research Report
The relationship between homeostatic inflammation and renin-angiotensin system in the progression of diabetic nephropathy
| Project/Area Number |
25860673
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Kidney internal medicine
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| Research Institution | Kumamoto University (2014)
Kyoto University (2013) |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | 自然炎症 / 糖尿病性腎症 / レニン・アンジオテンシン系 / MRP8 / 細胞間クロストーク |
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| Outline of Final Research Achievements |
We have previously observed that the macrophages (Mf) infiltrated in glomeruli showed higher MRP8 positivity compared to those in interstitium in diabetic nehropathy. TLR4 deletion did not ameliorate the worsening of diabetic nephropathy nor glomerular MRP8 upregulation by angiotensin II infusion. Besides, MRP8 upregulation in Mf stimulated with mesangilal cell-cultured medium was not altered by TLR4 antagonist. Taken together, MRP8 could become a novel therapeutic target rather than blockade of TLR4 especially in the pathogenesis associated with intraglomerular cross talk.
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| Free Research Field |
医歯薬学
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