2014 Fiscal Year Final Research Report
The Effects of DNA Damage Response on Renal Fibrosis
| Project/Area Number |
25860684
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Kidney internal medicine
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| Research Institution | Osaka City University |
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Principal Investigator |
KIZU Akane 大阪市立大学, 医学(系)研究科(研究院), 助教 (30623201)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | 線維化 / DNA損傷 / DNA修復 |
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| Outline of Final Research Achievements |
The DNA damage response is important for genome stability and cell survival. Recently, it has been reported that association between DNA damage response and aging and arteriosclerosis. These DNA damage are may play a role of process of aging associated disease. We found that phosphorylation of histone H2AX, one of the sensitive marker of DNA double strand breaks, is increased in fibrosis region in mouse model. Furthermore, Histone H2AX knockout mice significantly reduced fibrosis region after UUO. These findings suggested that the histone H2AX activation may have potential role of pro-fibrotic pathways.
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| Free Research Field |
医歯薬学
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