Developing a novel therapy for Parkinson disease using mesenchymal cell-derived glial cells

2015 Fiscal Year Final Research Report

• Project/Area Number: 25860716
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Neurology
• Research Institution: Kyushu University
• Principal Investigator: Matsuse Dai 九州大学, 医学(系)研究科(研究院), 助教 (70596395)
• Research Collaborator: OGATA HIDENORI ; FUJITA ATSUSHI
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 細胞移植治療 / 間葉系細胞 / シュワン細胞 / Muse細胞 / パーキンソン病

Outline of Final Research Achievements

At first, we induced to differentiate Schwann cells (BM-SCs) from bone marrow-derived mesenchymal cells (MSCs) of Wistar rats by adding several trophic factors. Hemiparkinsonian rats were induced, and cells were engrafted in the affected portion of the striatum. Immunohistochemical study indicated that transplanted cells had lost the characteristic of Schwann cells after transplantation and then been eliminated.
Then we decided to use Multi-lineage differentiating Stress Enduring (Muse) cells for transplantation. Muse cells were obtained from human bone marrow stem cells. We confirmed their expression of immature markers and ability of triploblastic differentiation. We will continue to develop the novel therapy for Parkinson disease with Muse cells.

Free Research Field

神経内科学