2014 Fiscal Year Final Research Report
Optogenetic neuromodulation for Parkinson's disease
| Project/Area Number |
25860724
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurology
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| Research Institution | Juntendo University |
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Principal Investigator |
OYAMA Genko 順天堂大学, 医学部, 准教授 (00407256)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | 光遺伝学 / ドパミン / 脳深部刺激療法 / チャネルロドプシン / アークロドプシン |
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| Outline of Final Research Achievements |
Deep brain stimulation (DBS), which utilizing electrical stimulation, has been clinically available for neuromodulation of Parkinson's disease. The electrical stimulation is nonselective, and the mechanism of DBS was unknown whether excitatory or inhibitory. In this study, we showed that dopamine release was controlled by illuminating light on dopaminergic neurons in which photosensitive protein was expressed. We established neuromodulation which can control dopaminergic release.
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| Free Research Field |
神経内科
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