Expression of Toll-like receptors in adult onset Still's disease

2014 Fiscal Year Final Research Report

• Project/Area Number: 25860811
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Collagenous pathology/Allergology
• Research Institution: Saga University
• Principal Investigator: SUEMATSU Rie 佐賀大学, 医学部, 助教 (80632322)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 成人スチル病 / Toll様受容体

Outline of Final Research Achievements

Adult-onset Still’s disease (AOSD) is a systemic inflammatory disease of uncertain etiology. It is suggested that some kind of infection participate in the onset of AOSD. Toll-like receptors (TLRs) are a family of receptors that recognizes microbial-associated molecular patterns from diverse organisms. We analyzed the activation of TLRs in AOSD patients. First, we measured soluble TLRs (sTLRs) levels in the sera from 10 patients with active AOSD and 10 controls, and found that sTLR2, 5, and 9 levels were increased in AOSD group. sTLR2 values correlated with ferritin and LDH; sTLR5 values correlated with ferritin, LDH and soluble IL-2 receptor levels in AOSD. Second, we examined the expressions of TLR mRNA in the peripheral blood cells by real-time PCR in 7 AOSD patients and 4 controls. Only TLR5 mRNA levels were significantly higher in AOSD. From these experiments, TLR5 is upregulated in AOSD and it is suggested that TLR5 may be the most important TLR in the development of AOSD.

Free Research Field

内科系臨床医学