2014 Fiscal Year Final Research Report
The pathogenesis of severe infections and the immunity in respiratory tract - New approach for anti-inflammatory treatment -
| Project/Area Number |
25860830
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Infectious disease medicine
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| Research Institution | Nagasaki University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | HMGB1 / 細胞死 |
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| Outline of Final Research Achievements |
TNFα contributes to the inhibition of bacterial growth in cells with inducting apoptotic cell death. Anaerobes produces some toxins and they may induces the receptors on the airway, which pneumococcus requires to attach to the respiratory tract. The toxins produced by anaerobes can progress the severity of pneumococcal pneumonia. The severity of infection may affect the effectiveness of antimicrobials in the treatment of pneumonia. Therefore, we need further studies for the evaluation of severity of infections and progress the strategies of choice the appropreate treatment.
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| Free Research Field |
感染症内科学
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