Autophagy evoked in airway epithelial cell play an important role in steroid resistant asthma.

2014 Fiscal Year Final Research Report

• Project/Area Number: 25860850
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Pediatrics
• Research Institution: University of Fukui
• Principal Investigator: MURAI HIROKI 福井大学, 医学部, 助教 (50464566)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: オートファジー / アレルギー / 気道上皮

Outline of Final Research Achievements

A fungi, Alternaria alternata, is reported to correlate with exacerbation of asthma. The roles of autophagy has been clarified. It plays an important role not only in homeostasis of cells, but also in immune response. We have previously reported that the stimulation of airway epithelial cells by Alternaria induces the release of IL-18. We then have hypothesized that this IL-18 from Alternaria stimulation is released by autophagy. In this project, we show that Alternaria and house dust mite release partially different kinds of cytokines. In addition, the major content of house dust mite, LPS, can also induce the autophagy, however the autophagy cascade stops on the way. As a result, house dust mite cannot induce the release of IL-18.

Free Research Field

アレルギー