Molecular mechanism of autism based on abnormalities of synaptic genes expression using iPS cells of Rett syndrome

2014 Fiscal Year Final Research Report

• Project/Area Number: 25860852
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Pediatrics
• Research Institution: University of Yamanashi
• Principal Investigator: MIYAKE Kunio 山梨大学, 総合研究部, 助教 (60550712)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: エピジェネティクス / 発達障害 / レット症候群 / iPS細胞 / DNAメチル化 / ヒストン修飾 / 自閉症

Outline of Final Research Achievements

We investigated the expression mechanisms of MeCP2 target genes in the neuronal cell lines and induced pluripotent stem cells (iPSCs) derived from Rett syndrome patients. As a result, we found that Lin7a gene was activated by MeCP2. Furthermore, we found that gene expression pattern was different between MeCP2 positive iPSCs-derived neural cells and MeCP2 negative cells. These results suggest that MeCP2 has an important function during neuronal differentiation and synaptic maturation.

Free Research Field

エピジェネティクス