2016 Fiscal Year Final Research Report
Monitoring cerebral hemodynamics and neural activiity using TRS and EEG can predict the severity of brain injury in asphyxiated newborn piglet
| Project/Area Number |
25860911
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Embryonic/Neonatal medicine
|
|---|
| Research Institution | Kagawa University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2013-04-01 – 2017-03-31
|
| Keywords | 新生仔豚 / 低酸素虚血 / 脳波抑制 / 脳血液量 |
|---|
| Outline of Final Research Achievements |
Monitoring cerebral neural suppression and hemodynamics using aEEG and Time resolved spectroscopy in asphyxiated piglet and HIE neonates.
The aim of this study is to examine the relationship between changes in cerebral blood volume (CBV) and and the low amplitude-integrated electroencephalography (aEEG) duration (LAEEG) after a HI insult. The following results had been reported. At first, there was a positive linear correlation between changes in cerebral blood volume and low-amplitude aEEG duration within 6h after HI insult. Secondly, asphyxiated piglets showed that their histopathological cerebral damages correlated with increase in CBV after HI insult. Furthermore, in clinical study, neonates with severe brain damage also showed increase in CBV within 12 h after birth compared with healthy neonates. Since, an early increase in CBV and longer LAEEG indicate severe brain injury.
|
| Free Research Field |
新生児
|
