The role of the microRNA and the signal pathway in psoriasis

2014 Fiscal Year Final Research Report

• Project/Area Number: 25860956
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Dermatology
• Research Institution: Kumamoto University
• Principal Investigator: ICHIHARA ASAKO 熊本大学, 大学院生命科学研究部, 助教 (20635784)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 乾癬 / microRNA / 薬疹 / 疾患マーカー

Outline of Final Research Achievements

There were several overexpressed or suppressed microRNAs specifically in the skin, sera and hair of psoriasis patients. Especially, the hair root miR-19a levels, regulatory microRNA of TNF-α, were significantly up-regulated only in psoriasis compared with normal controls. Investigation of microRNA in psoriasis may lead to a new disease activity marker. Furthermore, we also investigate the microRNAs in severe drug eruptions as contorols of psoriasis. Our results indicated that downregulated BCL2L10 caused by miR-18a-5p overexpression mediates intrinsic keratinocyte apoptosis in patients with toxic epidermal necrolysis. Serum miR-18a-5p levels can be a useful disease marker for drug eruptions.

Free Research Field

皮膚科学