• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2014 Fiscal Year Final Research Report

Search of the diagnotic biomarkers for depression

Research Project

  • PDF
Project/Area Number 25861009
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Psychiatric science
Research InstitutionHiroshima University

Principal Investigator

SEGAWA MASAHIRO  広島大学, 医歯薬保健学研究院, 特任助教 (20457253)

Project Period (FY) 2013-04-01 – 2015-03-31
Keywordsうつ病 / proBDNF / BDNFアンチセンス / 5-HTT / メチル化 / SLC6A4
Outline of Final Research Achievements

Comparison of the proBDNF (brain derived neurotrophic factor) density in the blood with the control (n=20) and the depression patient (n=5) didn't give us the significant difference. Leukocyte-derived BDNF antisense RNA was measured in real-time PCR. It was possible to measure with only the control (n=5). We had compared the methylation rate of CpG Island of SLC6A4 which is a manifested control part of a serotonin transporter (5-HTT) of the depression (n=50) with one of the control (n=50). We didn't have the result in line with expectations, but a possibility which can be the biomarker of the therapeutic responses to antidepressant.

Free Research Field

うつ病

URL: 

Published: 2016-06-03  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi