Effect of carbonyl stress on neural differentiation and development

2014 Fiscal Year Final Research Report

• Project/Area Number: 25861037
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Psychiatric science
• Research Institution: The Institute of Physical and Chemical Research
• Principal Investigator: TOYOSHIMA Manabu 独立行政法人理化学研究所, 脳科学総合研究センター, 基礎科学特別研究員 (90582750)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 統合失調症 / カルボニルストレス / 終末糖化産物 / iPS細胞 / 神経発達 / AGEs

Outline of Final Research Achievements

In this study, we have focused on the relationship between carbonyl stress and abnormal neural differentiation and development in schizophrenic patient, examined the influence of advanced glycation end products (AGEs) on neural differentiation efficiencies by using iPS cells derived from the schizophrenia patients. Patients iPS cells showed specific AGEs compared to control iPSC. We have found that there is a specificity in proteins that preferentially react with AGEs. We differentiated iPS cells into neurospheres. Neural differentiation efficiencies were decreased in patients iPS cells. Inhibition of carbonyl stress allowed patients neurospheres to recover from decrease in neural differentiation efficiencies.

Free Research Field

医歯薬学