Radiotherapy targeting hypoxic cancer cells: research for biologically appropriate method of dose delivery

2015 Fiscal Year Final Research Report

• Project/Area Number: 25861046
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Hokkaido University
• Principal Investigator: YASUDA Koichi 北海道大学, 医学(系)研究科(研究院), 特任助教 (00431362)
• Research Collaborator: NISHIKAWA Yukiko 北海道大学, 医学研究科, 大学院生
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 低酸素イメージング / FMISO-PET

Outline of Final Research Achievements

Although hypoxic cancer cell is shown to be radio-resistance in vitro and vivo, the clinical impact of cancer-hypoxia is not clear. Before radiation therapy, we performed FMISO-PET, which is one of hypoxia imagings. The locational relationship between the site of FMISO uptake and local relapse was examined. In the analysis of small voxel (1 x 1 x 2mm), it was indicated that the site with higher FMISO uptake had a higher probability of local recurrence than lower uptake in relapse patients. The simulation study of dose-escalation radiation therapy targeting hypoxic region was performed.
Some results of this research was published at the annual American Society of Radiation Oncology meeting, which is world-leading conference in radiation oncology.

Free Research Field

放射線治療