2015 Fiscal Year Final Research Report
Anticancer therapy controlling vascular permeability in interventional radiology
| Project/Area Number |
25861078
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Radiation science
|
|---|
| Research Institution | Kanazawa University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Keywords | 血管透過性 / permeability / IVR |
|---|
| Outline of Final Research Achievements |
In this project, we obtained the protocol of noninvasive intravascular interventional approach from femoral artery and catheterization to selective hepatic arteries. In steady condition, there is no sign of extravasation of FITC-dextran injected from hepatic artery. And there is no sign of extravasation of FITX-dextran in the drug administration model of nitroglycerin, sodium nitroprusside, histamine, and platelet activating factor. On the other hand, in liver VX-2 tumor model, the hyper-vascular permeability was observed at the peritumoral area in administration of nitroglycerin.
|
| Free Research Field |
放射線科
|
