Establishment of tumor blood flow imaging to predict the chemotherapy effect for lung caner

2015 Fiscal Year Final Research Report

• Project/Area Number: 25861092
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Osaka University
• Principal Investigator: Yanagawa Masahiro 大阪大学, 医学(系)研究科(研究院), 助教 (00546872)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 肺癌 / 腫瘍血流 / 水PET/CT / VEGF

Outline of Final Research Achievements

The purpose of this study was to establish tumor blood flow imaging by evaluating tumor blood flow in patients with non small cell lung cancer (NSCLC) before and after treatment of (BEV) using 15O-water PET and CT perfusion. There was a significant difference between tumor blood flow before and after chemotherapy with BEV. Large decrease in blood flow early after treatment of BEV was associated with short time to tumor progression. The antiangeonenic therapy might not have benefit for the patients with tumor blood flow decrease early after BEV.

Free Research Field

放射線医学