Effectiveness of bone marrow sparing IMRT using FLT-PET

2015 Fiscal Year Final Research Report

• Project/Area Number: 25861097
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Osaka University
• Principal Investigator: ISOHASHI Fumiaki 大阪大学, 医学(系)研究科(研究院), 准教授 (00448036)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 放射線治療学 / 急性期有害事象 / 骨髄抑制

Outline of Final Research Achievements

Pelvic radiotherapy contributes significantly to the development of hematologic toxicity (HT). More than one-half of the body's bone marrow is located in pelvic bones. To purpose of this study was to evaluate bone marrow sparing intensity modulated radiotherapy (IMRT). The main results of this study as follows;
Patients treated with bowel sparing IMRT had a higher incidence of acute HT. The volume of the pelvic bone receiving relatively high-dose (V40-45 Gy) radiation is associated with acute HT. In conclusion, techniques to limit the pelvic bone irradiation may reduce acute HT.

Free Research Field

放射線治療学